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Efficient and Selective Formation of Macrocyclic Disubstituted Z Alkenes by Ring-Closing Metathesis (RCM) Reactions Catalyzed by Mo- or W-Based Monoaryloxide Pyrrolide (MAP) Complexes. Applications to Total Syntheses of Epilachnene, Yuzu Lactone, Ambrettolide, Epothilone C and Nakadomarin A

[Image: see text] The first broadly applicable set of protocols for efficient and highly Z-selective formation of macrocyclic disubstituted alkenes through catalytic ring-closing metathesis (RCM) is described. Cyclizations are performed in the presence of 1.2–7.5 mol % of a Mo- or W-based mono-arylo...

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Detalhes bibliográficos
Main Authors: Wang, Chenbo, Yu, Miao, Kyle, Andrew F., Jakubec, Jakubec, Dixon, Darren J., Schrock, Richard R., Hoveyda, Amir H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3996920/
https://ncbi.nlm.nih.gov/pubmed/23345004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201204045
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