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Negative Regulation of Hif1a Expression and T(H)17 Differentiation by Hypoxia Regulated miR-210
MicroRNA-210 (miR-210) is a signature microRNA of hypoxia. We found robust increase (>100-fold) of miR-210 abundance in activated T cells, especially in the T(H)17 lineage. Hypoxia synergized with T cell receptor (TCR)–CD28 stimulation to accelerate and increase the magnitude of Mir210 expression...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3996831/ https://ncbi.nlm.nih.gov/pubmed/24608041 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2846 |
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