Integrative analyses of genetic variation, epigenetic regulation, and the transcriptome to elucidate the biology of platinum sensitivity

BACKGROUND: Using genome-wide genetic, gene expression, and microRNA expression (miRNA) data, we developed an integrative approach to investigate the genetic and epigenetic basis of chemotherapeutic sensitivity. RESULTS: Through a sequential multi-stage framework, we identified genes and miRNAs whos...

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Detalhes bibliográficos
Main Authors: LaCroix, Bonnie, Gamazon, Eric R, Lenkala, Divya, Im, Hae Kyung, Geeleher, Paul, Ziliak, Dana, Cox, Nancy J, Huang, Rong Stephanie
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Methodology Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3996490/
https://ncbi.nlm.nih.gov/pubmed/24739237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-15-292
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