Hepatic ATGL mediates PPAR-α signaling and fatty acid channeling through an L-FABP independent mechanism

Adipose TG lipase (ATGL) catalyzes the rate-limiting step in TG hydrolysis in most tissues. We have shown that hepatic ATGL preferentially channels hydrolyzed FAs to β-oxidation and induces PPAR-α signaling. Previous studies have suggested that liver FA binding protein (L-FABP) transports FAs from l...

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Bibliografiske detaljer
Main Authors: Ong, Kuok Teong, Mashek, Mara T., Davidson, Nicholas O., Mashek, Douglas G.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2014
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3995459/
https://ncbi.nlm.nih.gov/pubmed/24610891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M039867
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