Retinoic Acid Regulation of Hemogenic Endothelial Cell Specification Requires c-Kit, Notch Signaling and p27-mediated Cell Cycle Control

Delineating the mechanism(s) that regulate the specification of hemogenic endothelial cells from primordial endothelium is critical for optimizing their derivation from human stem cells for clinical therapies. We previously determined that retinoic acid (RA) is required for hemogenic specification,...

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Главные авторы: Marcelo, Kathrina L., Sills, Tiffany M., Coskun, Suleyman, Vasavada, Hema, Sanglikar, Supriya, Goldie, Lauren C., Hirschi, Karen K.
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3994666/
https://ncbi.nlm.nih.gov/pubmed/24331925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2013.11.004
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