Amplification of Aminoglycoside Resistance Gene aphA1 in Acinetobacter baumannii Results in Tobramycin Therapy Failure

Gene amplification is believed to play an important role in antibiotic resistance but has been rarely documented in clinical settings because of its unstable nature. We report a rise in MICs from 0.5 to 16 μg/ml in successive Acinetobacter baumannii isolated over 4 days from a patient being treated...

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Detalhes bibliográficos
Main Authors: McGann, Patrick, Courvalin, Patrice, Snesrud, Erik, Clifford, Robert J., Yoon, Eun-Jeong, Onmus-Leone, Fatma, Ong, Ana C., Kwak, Yoon I., Grillot-Courvalin, Catherine, Lesho, Emil, Waterman, Paige E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Microbiology 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3994513/
https://ncbi.nlm.nih.gov/pubmed/24757213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00915-14
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