BREAST CANCER-ASSOCIATED MISSENSE MUTANTS OF THE PALB2 WD40 DOMAIN, WHICH DIRECTLY BINDS RAD51C, RAD51 AND BRCA2, DISRUPT DNA REPAIR

Heterozygous carriers of germ-line mutations in the BRCA2/FANCD1, PALB2/FANCN, and RAD51C/FANCO DNA repair genes have an increased life-time risk to develop breast, ovarian and other cancers; bi-allelic mutations in these genes clinically manifest as Fanconi anemia (FA). Here, we demonstrate that RA...

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Detalhes bibliográficos
Main Authors: Park, Jung-Young, Singh, Thiyam R., Nassar, Nicolas, Zhang, Fan, Freund, Marcel, Hanenberg, Helmut, Meetei, Amom Ruhikanta, Andreassen, Paul R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3994186/
https://ncbi.nlm.nih.gov/pubmed/24141787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.421
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