The PTH-Gα(s)-Protein Kinase A Cascade Controls αNAC Localization To Regulate Bone Mass

The binding of PTH to its receptor induces Gα(s)-dependent cyclic AMP (cAMP) accumulation to turn on effector kinases, including protein kinase A (PKA). The phenotype of mice with osteoblasts specifically deficient for Gα(s) is mimicked by a mutation leading to cytoplasmic retention of the transcrip...

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Detalhes bibliográficos
Main Authors: Pellicelli, Martin, Miller, Julie A., Arabian, Alice, Gauthier, Claude, Akhouayri, Omar, Wu, Joy Y., Kronenberg, Henry M., St-Arnaud, René
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993600/
https://ncbi.nlm.nih.gov/pubmed/24550008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01434-13
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