Induction of HIV-Blocking Anti-CCR5 IgA in Peyers's Patches without Histopathological Alterations

The chemokine receptor CCR5 is essential for HIV infection and is thus a potential target for vaccine development. However, because CCR5 is a host protein, generation of anti-CCR5 antibodies requires the breaking of immune tolerance and thus carries the risk of autoimmune responses. In this study, p...

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Autors principals: Pastori, Claudia, Diomede, Lorenzo, Venuti, Assunta, Fisher, Gregory, Jarvik, Jonathan, Bomsel, Morgane, Sanvito, Francesca, Lopalco, Lucia
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
Matèries:
Vaccines and Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993546/
https://ncbi.nlm.nih.gov/pubmed/24403594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03663-13
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