Discovery of Compounds Blocking the Proliferation of Toxoplasma gondii and Plasmodium falciparum in a Chemical Space Based on Piperidinyl-Benzimidazolone Analogs

A piperidinyl-benzimidazolone scaffold has been found in the structure of different inhibitors of membrane glycerolipid metabolism, acting on enzymes manipulating diacylglycerol and phosphatidic acid. Screening a focus library of piperidinyl-benzimidazolone analogs might therefore identify compounds...

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Main Authors: Saïdani, Nadia, Botté, Cyrille Y., Deligny, Michael, Bonneau, Anne-Laure, Reader, Janette, Lasselin, Ronald, Merer, Goulven, Niepceron, Alisson, Brossier, Fabien, Cintrat, Jean-Christophe, Rousseau, Bernard, Birkholtz, Lyn-Marie, Cesbron-Delauw, Marie-France, Dubremetz, Jean-François, Mercier, Corinne, Vial, Henri, Lopez, Roman, Maréchal, Eric
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2014
Assuntos:
Susceptibility
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993238/
https://ncbi.nlm.nih.gov/pubmed/24550329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01445-13
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