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IL-6 controls susceptibility to helminth infection by impeding Th2 responsiveness and altering the Treg phenotype in vivo

IL-6 plays a pivotal role in favoring T-cell commitment toward a Th17 cell rather than Treg-cell phenotype, as established through in vitro model systems. We predicted that in the absence of IL-6, mice infected with the gastrointestinal helminth Heligmosomoides polygyrus would show reduced Th17-cell...

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Sonraí Bibleagrafaíochta
Main Authors: Smith, Katherine A, Maizels, Rick M
Formáid: Artigo
Teanga:Inglês
Foilsithe: Blackwell Publishing Ltd 2014
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992848/
https://ncbi.nlm.nih.gov/pubmed/24185641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201343746
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