Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis

The family with sequence similarity 20, member C (Fam20C) has recently been identified as the Golgi casein kinase. Fam20C phosphorylates secreted proteins on Ser-x-Glu/pSer motifs and loss-of-function mutations in the kinase cause Raine syndrome, an often-fatal osteosclerotic bone dysplasia. Fam20C...

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Autors principals: Tagliabracci, Vincent S., Engel, James L., Wiley, Sandra E., Xiao, Junyu, Gonzalez, David J., Nidumanda Appaiah, Hitesh, Koller, Antonius, Nizet, Victor, White, Kenneth E., Dixon, Jack E.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2014
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992636/
https://ncbi.nlm.nih.gov/pubmed/24706917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1402218111
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