Novel withanolides target medullary thyroid cancer through inhibition of both RET phosphorylation and the mammalian target of rapamycin pathway

BACKGROUND: Despite development of current targeted therapies for medullary thyroid cancer (MTC), long-term survival remains unchanged. Recently isolated novel withanolide compounds from Solanaceae physalis are highly potent against MTCs. We hypothesize that these withanolides uniquely inhibit RET p...

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Detalhes bibliográficos
Main Authors: Samadi, Abbas K., Bazzill, Joseph, Zhang, Xuan, Gallagher, Rob, Zhang, Hauping, Gollapudi, Rao, Kindscher, Kelly, Timmermann, Barbara, Cohen, Mark S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992287/
https://ncbi.nlm.nih.gov/pubmed/23158190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.surg.2012.08.031
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