Population Pharmacokinetics of Oral Baclofen in Pediatric Patients with Cerebral Palsy

OBJECTIVE: To characterize the population pharmacokinetics (PK) of oral baclofen and assess impact of patient-specific covariates in children with cerebral palsy (CP) in order to support its clinical use. SUBJECTS DESIGN: Children (2-17 years of age) with CP received a dose of titrated oral baclofen...

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Détails bibliographiques
Auteurs principaux: He, Yang, Brunstrom-Hernandez, Janice E., Thio, Liu Lin, Lackey, Shellie, Gaebler-Spira, Deborah, Kuroda, Maxine M., Stashinko, Elaine, Hoon, Alexander H., Vargus-Adams, Jilda, Stevenson, Richard D., Lowenhaupt, Stephanie, McLaughlin, John F., Christensen, Ana, Dosa, Nienke P., Butler, Maureen, Schwabe, Aloysia, Lopez, Christina, Roge, Desiree, Kennedy, Diane, Tilton, Ann, Krach, Linda E., Lewandowski, Andrew, Dai, Hongying, Gaedigk, Andrea, Leeder, J. Steven, Jusko, William J.
Format: Artigo
Langue:Inglês
Publié: 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992203/
https://ncbi.nlm.nih.gov/pubmed/24607242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpeds.2014.01.029
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