Population Pharmacokinetics of Oral Baclofen in Pediatric Patients with Cerebral Palsy

OBJECTIVE: To characterize the population pharmacokinetics (PK) of oral baclofen and assess impact of patient-specific covariates in children with cerebral palsy (CP) in order to support its clinical use. SUBJECTS DESIGN: Children (2-17 years of age) with CP received a dose of titrated oral baclofen...

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Päätekijät: He, Yang, Brunstrom-Hernandez, Janice E., Thio, Liu Lin, Lackey, Shellie, Gaebler-Spira, Deborah, Kuroda, Maxine M., Stashinko, Elaine, Hoon, Alexander H., Vargus-Adams, Jilda, Stevenson, Richard D., Lowenhaupt, Stephanie, McLaughlin, John F., Christensen, Ana, Dosa, Nienke P., Butler, Maureen, Schwabe, Aloysia, Lopez, Christina, Roge, Desiree, Kennedy, Diane, Tilton, Ann, Krach, Linda E., Lewandowski, Andrew, Dai, Hongying, Gaedigk, Andrea, Leeder, J. Steven, Jusko, William J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2014
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992203/
https://ncbi.nlm.nih.gov/pubmed/24607242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpeds.2014.01.029
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