Population Pharmacokinetics of Oral Baclofen in Pediatric Patients with Cerebral Palsy

OBJECTIVE: To characterize the population pharmacokinetics (PK) of oral baclofen and assess impact of patient-specific covariates in children with cerebral palsy (CP) in order to support its clinical use. SUBJECTS DESIGN: Children (2-17 years of age) with CP received a dose of titrated oral baclofen...

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Autores principales: He, Yang, Brunstrom-Hernandez, Janice E., Thio, Liu Lin, Lackey, Shellie, Gaebler-Spira, Deborah, Kuroda, Maxine M., Stashinko, Elaine, Hoon, Alexander H., Vargus-Adams, Jilda, Stevenson, Richard D., Lowenhaupt, Stephanie, McLaughlin, John F., Christensen, Ana, Dosa, Nienke P., Butler, Maureen, Schwabe, Aloysia, Lopez, Christina, Roge, Desiree, Kennedy, Diane, Tilton, Ann, Krach, Linda E., Lewandowski, Andrew, Dai, Hongying, Gaedigk, Andrea, Leeder, J. Steven, Jusko, William J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992203/
https://ncbi.nlm.nih.gov/pubmed/24607242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpeds.2014.01.029
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