Population Pharmacokinetics of Oral Baclofen in Pediatric Patients with Cerebral Palsy

OBJECTIVE: To characterize the population pharmacokinetics (PK) of oral baclofen and assess impact of patient-specific covariates in children with cerebral palsy (CP) in order to support its clinical use. SUBJECTS DESIGN: Children (2-17 years of age) with CP received a dose of titrated oral baclofen...

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Κύριοι συγγραφείς: He, Yang, Brunstrom-Hernandez, Janice E., Thio, Liu Lin, Lackey, Shellie, Gaebler-Spira, Deborah, Kuroda, Maxine M., Stashinko, Elaine, Hoon, Alexander H., Vargus-Adams, Jilda, Stevenson, Richard D., Lowenhaupt, Stephanie, McLaughlin, John F., Christensen, Ana, Dosa, Nienke P., Butler, Maureen, Schwabe, Aloysia, Lopez, Christina, Roge, Desiree, Kennedy, Diane, Tilton, Ann, Krach, Linda E., Lewandowski, Andrew, Dai, Hongying, Gaedigk, Andrea, Leeder, J. Steven, Jusko, William J.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2014
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Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992203/
https://ncbi.nlm.nih.gov/pubmed/24607242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpeds.2014.01.029
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