Enhanced and accelerated lymphoproliferation in Fas-null mice.

Fas is a 45-kDa membrane protein that transduces an apoptotic signal. The mouse lymphoproliferation (lpr) mutation is a leaky mutation of Fas. In this study, we examined lymphocyte development in Fas-null mice generated by gene targeting. The Fas-/- mice progressively accumulated abnormal T cells (T...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Adachi, M, Suematsu, S, Suda, T, Watanabe, D, Fukuyama, H, Ogasawara, J, Tanaka, T, Yoshida, N, Nagata, S
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39922/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8700897/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.5.2131
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