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Effects of Preoperative Hypoxia on White Matter Injury Associated with Cardiopulmonary Bypass in a Rodent Hypoxic and Brain Slice Model

BACKGROUND: White matter (WM) injury is common after cardiopulmonary bypass or deep hypothermic circulatory arrest (DHCA) in neonates who have cerebral immaturity secondary to in utero hypoxia. The mechanism remains unknown. We investigated effects of preoperative-hypoxia on DHCA-induced WM-injury u...

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Bibliographic Details
Main Authors: Agematsu, Kota, Korotcova, Ludmila, Scafidi, Joseph, Gallo, Vittorio, Jonas, Richard A., Ishibashi, Nobuyuki
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992169/
https://ncbi.nlm.nih.gov/pubmed/24488087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/pr.2014.9
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