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Defects in GABA metabolism affect selective autophagy pathways and are alleviated by mTOR inhibition
In addition to key roles in embryonic neurogenesis and myelinogenesis, γ-aminobutyric acid (GABA) serves as the primary inhibitory mammalian neurotransmitter. In yeast, we have identified a new role for GABA that augments activity of the pivotal kinase, Tor1. GABA inhibits the selective autophagy pa...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Backwell Publishing Ltd
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3992080/ https://ncbi.nlm.nih.gov/pubmed/24578415 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201303356 |
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