Defects in GABA metabolism affect selective autophagy pathways and are alleviated by mTOR inhibition

In addition to key roles in embryonic neurogenesis and myelinogenesis, γ-aminobutyric acid (GABA) serves as the primary inhibitory mammalian neurotransmitter. In yeast, we have identified a new role for GABA that augments activity of the pivotal kinase, Tor1. GABA inhibits the selective autophagy pa...

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Autores principales: Lakhani, Ronak, Vogel, Kara R, Till, Andreas, Liu, Jingjing, Burnett, Sarah F, Gibson, K Michael, Subramani, Suresh
Formato: Artigo
Lenguaje:Inglês
Publicado: Backwell Publishing Ltd 2014
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992080/
https://ncbi.nlm.nih.gov/pubmed/24578415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201303356
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