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Stereospecific Nickel-Catalyzed Cross-Coupling Reactions of Alkyl Grignard Reagents and Identification of Selective Anti-Breast Cancer Agents

β-Hydrogen-containing alkyl Grignard reagents were used in a stereospecific nickel-catalyzed cross-coupling reaction to form sp(3)–sp(3) carbon–carbon bonds. Aryl Grignard reagents were also utilized to synthesize 1,1-diarylalkanes. Several compounds synthesized by this method exhibited selective in...

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Main Authors: Yonova, Ivelina M., Johnson, A. George, Osborne, Charlotte A., Moore, Curtis E., Morrissette, Naomi S., Jarvo, Elizabeth R.
格式: Artigo
語言:Inglês
出版: 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3991427/
https://ncbi.nlm.nih.gov/pubmed/24478275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201308666
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