Intracytoplasmic Sperm Injection Using DNA-Fragmented Sperm in Mice Negatively Affects Embryo-Derived Embryonic Stem Cells, Reduces the Fertility of Male Offspring and Induces Heritable Changes in Epialleles

Intracytoplasmic sperm injection (ICSI) in mice using DNA-fragmented sperm (DFS) has been linked to an increased risk of genetic and epigenetic abnormalities both in embryos and offspring. This study examines: whether embryonic stem cells (ESCs) derived from DFS-ICSI embryos reflect the abnormalitie...

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Main Authors: Ramos-Ibeas, Priscila, Calle, Alexandra, Fernández-González, Raúl, Laguna-Barraza, Ricardo, Pericuesta, Eva, Calero, Antonia, Ramírez, Miguel Ángel, Gutiérrez-Adán, Alfonso
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3990723/
https://ncbi.nlm.nih.gov/pubmed/24743851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0095625
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