A Genome-wide Association Study of Early-onset Breast Cancer Identifies PFKM as a Novel Breast Cancer Gene and Supports a Common Genetic Spectrum for Breast Cancer at Any Age

Early-onset breast cancer (EOBC) causes substantial loss of life and productivity, creating a major burden among women worldwide. We analyzed 1,265,548 Hapmap3 SNPs among a discovery set of 3,523 EOBC incident case and 2,702 population control women aged <=51 years. The SNPs with smallest P-value...

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Main Authors: Ahsan, Habibul, Halpern, Jerry, Kibriya, Muhammad G, Pierce, Brandon L, Tong, Lin, Gamazon, Eric, McGuire, Valerie, Felberg, Anna, Shi, Jianxin, Jasmine, Farzana, Roy, Shantanu, Brutus, Rachelle, Argos, Maria, Melkonian, Stephanie, Chang-Claude, Jenny, Andrulis, Irene, Hopper, John L, John, Esther M., Malone, Kathi, Ursin, Giske, Gammon, Marilie D, Thomas, Duncan C, Seminara, Daniela, Casey, Graham, Knight, Julia A, Southey, Melissa C, Giles, Graham G, Santella, Regina M, Lee, Eunjung, Conti, David, Duggan, David, Gallinger, Steve, Haile, Robert, Jenkins, Mark, Lindor, Noralane M, Newcomb, Polly, Michailidou, Kyriaki, Apicella, Carmel, Park, Daniel J, Peto, Julian, Fletcher, Olivia, Silva, Isabel dos Santos, Lathrop, Mark, Hunter, David J, Chanock, Stephen J, Meindl, Alfons, Schmutzler, Rita K, Müller-Myhsok, Bertram, Lochmann, Magdalena, Beckmann, Lars, Hein, Rebecca, Makalic, Enes, Schmidt, Daniel F, Bui, Quang Minh, Stone, Jennifer, Flesch-Janys, Dieter, Dahmen, Norbert, Nevanlinna, Heli, Aittomäki, Kristiina, Blomqvist, Carl, Hall, Per, Czene, Kamila, Irwanto, Astrid, Liu, Jianjun, Rahman, Nazneen, Turnbull, Clare, Dunning, Alison M., Pharoah, Paul, Waisfisz, Quinten, Meijers-Heijboer, Hanne, Uitterlinden, Andre G., Rivadeneira, Fernando, Nicolae, Dan, Easton, Douglas F, Cox, Nancy J, Whittemore, Alice S
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3990360/
https://ncbi.nlm.nih.gov/pubmed/24493630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-13-0340
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