Mice That Express Human Interleukin-8 Have Increased Mobilization of Immature Myeloid Cells, Which Exacerbates Inflammation and Accelerates Colon Carcinogenesis

BACKGROUND & AIMS: Interleukin (IL)-8 has an important role in initiating inflammation in humans, attracting immune cells such as neutrophils through their receptors CXCR1 and CXCR2. IL-8 has been proposed to contribute to chronic inflammation and cancer. However, mice do not have the IL-8 gene,...

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Main Authors: ASFAHA, SAMUEL, DUBEYKOVSKIY, ALEXANDER N., TOMITA, HIROYUKI, YANG, XIANGDONG, STOKES, SARAH, SHIBATA, WATARU, FRIEDMAN, RICHARD A., ARIYAMA, HIROSHI, DUBEYKOVSKAYA, ZINAIDA A., MUTHUPALANI, SURESHKUMAR, ERICKSEN, RUSSELL, FRUCHT, HAROLD, FOX, JAMES G., WANG, TIMOTHY C.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3990262/
https://ncbi.nlm.nih.gov/pubmed/23041326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2012.09.057
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