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Activation of adenosine receptor A(2A) increases HSC proliferation and inhibits death and senescence by down-regulation of p53 and Rb

Background and Aims: During fibrosis hepatic stellate cells (HSC) undergo activation, proliferation, and senescence but the regulation of these important processes is poorly understood. The adenosine A(2A) receptor (A(2A)) is known to be present on HSC, and its activation results in liver fibrosis....

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Détails bibliographiques
Auteurs principaux: Ahsan, Md. Kaimul, Mehal, Wajahat Z.
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989592/
https://ncbi.nlm.nih.gov/pubmed/24782773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2014.00069
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