Strong Vaccine-Induced CD8 T-Cell Responses Have Cytolytic Function in a Chimpanzee Clearing HCV Infection

A single correlate of effective vaccine protection against chronic HCV infection has yet to be defined. In this study, we analyzed T-cell responses in four chimpanzees, immunized with core-E1-E2-NS3 and subsequently infected with HCV1b. Viral clearance was observed in one animal, while the other thr...

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Detalhes bibliográficos
Main Authors: Verstrepen, Babs E., Verschoor, Ernst J., Fagrouch, Zahra C., Mooij, Petra, de Groot, Natasja G., Bontrop, Ronald E., Bogers, Willy M., Heeney, Jonathan L., Koopman, Gerrit
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989318/
https://ncbi.nlm.nih.gov/pubmed/24740375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0095103
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