Bis(monoacylglycero)phosphate accumulation in macrophages induces intracellular cholesterol redistribution, attenuates liver-X receptor/ATP-Binding cassette transporter A1/ATP-binding cassette transporter G1 pathway, and impairs cholesterol efflux

OBJECTIVE: Endosomal signature phospholipid bis(monoacylglycero)phosphate (BMP) has been involved in the regulation of cellular cholesterol homeostasis. Accumulation of BMP is a hallmark of lipid storage disorders and was recently reported as a noticeable feature of oxidized LDL-laden macrophages. T...

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Detalhes bibliográficos
Main Authors: Luquain-Costaz, Céline, Lefai, Etienne, Arnal-Levron, Maud, Markina, Daria, Sakaï, Shota, Euthine, Vanessa, Makino, Asami, Guichardant, Michel, Yamashita, Shizuya, Kobayashi, Toshihide, Lagarde, Michel, Moulin, Philippe, Delton-Vandenbroucke, Isabelle
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989212/
https://ncbi.nlm.nih.gov/pubmed/23788762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.113.301857
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