Nucleocytosolic Depletion of the Energy Metabolite Acetyl-Coenzyme A Stimulates Autophagy and Prolongs Lifespan

Healthy aging depends on removal of damaged cellular material that is in part mediated by autophagy. The nutritional status of cells affects both aging and autophagy through as-yet-elusive metabolic circuitries. Here, we show that nucleocytosolic acetyl-coenzyme A (AcCoA) production is a metabolic r...

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Main Authors: Eisenberg, Tobias, Schroeder, Sabrina, Andryushkova, Aleksandra, Pendl, Tobias, Küttner, Victoria, Bhukel, Anuradha, Mariño, Guillermo, Pietrocola, Federico, Harger, Alexandra, Zimmermann, Andreas, Moustafa, Tarek, Sprenger, Adrian, Jany, Evelyne, Büttner, Sabrina, Carmona-Gutierrez, Didac, Ruckenstuhl, Christoph, Ring, Julia, Reichelt, Wieland, Schimmel, Katharina, Leeb, Tina, Moser, Claudia, Schatz, Stefanie, Kamolz, Lars-Peter, Magnes, Christoph, Sinner, Frank, Sedej, Simon, Fröhlich, Kai-Uwe, Juhasz, Gabor, Pieber, Thomas R., Dengjel, Jörn, Sigrist, Stephan J., Kroemer, Guido, Madeo, Frank
格式: Artigo
語言:Inglês
出版: Cell Press 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3988959/
https://ncbi.nlm.nih.gov/pubmed/24606900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2014.02.010
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