Neonatal Leptin Deficiency Reduces Frontal Cortex Volumes and Programs Adult Hyperactivity in Mice

Intrauterine growth restriction and premature delivery decrease circulating levels of the neurotrophic hormone leptin and increase the risk of adult psychiatric disease. In mouse models, neonatal leptin replacement normalizes brain growth and improves the neurodevelopmental outcomes of growth restri...

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Hauptverfasser: Dexter, Benjamin C, Rahmouni, Kamal, Cushman, Taylor, Hermann, Gregory M, Ni, Charles, Nopoulos, Peg C, Thedens, Daniel L, Roghair, Robert D
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3988698/
https://ncbi.nlm.nih.gov/pubmed/24472638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbr.2014.01.021
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