CSF Apo-E levels associate with cognitive decline and MRI changes

Apolipoprotein E (APOE) ε4 allele is the most important genetic risk factor for Alzheimer’s disease (AD) and it is thought to do so by modulating levels of the its product, apolipoprotein E (Apo-E), and regulating amyloid-β (Aβ) clearance. However, information on clinical and biomarker correlates of...

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Autors principals: Toledo, Jon B., Da, Xiao, Weiner, Michael W., Wolk, David A., Xie, Sharon X., Arnold, Steven E., Davatzikos, Christos, Shaw, Leslie M., Trojanowski, John Q.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3988233/
https://ncbi.nlm.nih.gov/pubmed/24385135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-013-1236-0
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