Increased SOX2 Gene Copy Number Is Associated with FGFR1 and PIK3CA Gene Gain in Non-Small Cell Lung Cancer and Predicts Improved Survival in Early Stage Disease

BACKGROUND: We aimed to investigate prevalence and prognostic role of SOX2, PIK3CA, FGFR1 and BRF2 gene gain in patients with surgically resected non-small cell lung cancer (NSCLC). METHODS: SOX2, PIK3CA, FGFR1 and BRF2 gene copy number was assessed by fluorescence in situ hybridization (FISH) in ar...

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Main Authors: Toschi, Luca, Finocchiaro, Giovanna, Nguyen, Teresa T., Skokan, Margaret C., Giordano, Laura, Gianoncelli, Letizia, Perrino, Matteo, Siracusano, Licia, Di Tommaso, Luca, Infante, Maurizio, Alloisio, Marco, Roncalli, Massimo, Scorsetti, Marta, Jänne, Pasi A., Santoro, Armando, Varella-Garcia, Marileila
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3988173/
https://ncbi.nlm.nih.gov/pubmed/24736592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0095303
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