The TrkAIII Oncoprotein Inhibits Mitochondrial Free Radical ROS-Induced Death of SH-SY5Y Neuroblastoma Cells by Augmenting SOD2 Expression and Activity at the Mitochondria, within the Context of a Tumour Stem Cell-like Phenotype

The developmental and stress-regulated alternative TrkAIII splice variant of the NGF receptor TrkA is expressed by advanced stage human neuroblastomas (NBs), correlates with worse outcome in high TrkA expressing unfavourable tumours and exhibits oncogenic activity in NB models. In the present study,...

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Hauptverfasser: Ruggeri, Pierdomenico, Farina, Antonietta R., Di Ianni, Natalia, Cappabianca, Lucia, Ragone, Marzia, Ianni, Giulia, Gulino, Alberto, Mackay, Andrew R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3988074/
https://ncbi.nlm.nih.gov/pubmed/24736663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094568
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