Activation of GPER-1 Estradiol Receptor Downregulates Production of Testosterone in Isolated Rat Leydig Cells and Adult Human Testis

PURPOSE: Estradiol (E2) modulates testicular functions including steroidogenesis, but the mechanisms of E2 signaling in human testis are poorly understood. GPER-1 (GPR30), a G protein-coupled membrane receptor, mediates rapid genomic and non-genomic response to estrogens. The aim of this study was t...

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Detalhes bibliográficos
Main Authors: Vaucher, Laurent, Funaro, Michael G., Mehta, Akanksha, Mielnik, Anna, Bolyakov, Alexander, Prossnitz, Eric R., Schlegel, Peter N., Paduch, Darius A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3987996/
https://ncbi.nlm.nih.gov/pubmed/24736568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092425
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