Endogenous Positive Allosteric Modulation of GABA(A) Receptors by Diazepam binding inhibitor

Benzodiazepines (BZs) allosterically modulate γ-aminobutyric acid type-A receptors (GABA(A)Rs) to increase inhibitory synaptic strength. Diazepam binding inhibitor (DBI) protein is a BZ site ligand expressed endogenously in the brain, but functional evidence for BZ-mimicking positive modulatory acti...

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Main Authors: Christian, Catherine A., Herbert, Anne G., Holt, Rebecca L., Peng, Kathy, Sherwood, Kyla D., Pangratz-Fuehrer, Susanne, Rudolph, Uwe, Huguenard, John R.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3987987/
https://ncbi.nlm.nih.gov/pubmed/23727119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2013.04.026
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