Subtype-specific Conservation of Isoleucine 309 in the Envelope V3 Domain is Linked to Immune Evasion in Subtype C HIV-1 Infection

The V3 region of the HIV-1 envelope (Env) glycoprotein gp120 is a key functional domain yet it exhibits distinct mutational patterns across subtypes. Here an invariant residue (Ile 309) was replaced with Leu in 7 subtype C patient-derived Envs from recent infection and 4 related neutralizing antibod...

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Main Authors: Lynch, Rebecca M., Rong, Rong, Li, Bing, Shen, Tongye, Honnen, William, Mulenga, Joseph, Allen, Susan, Pinter, Abraham, Gnanakaran, S., Derdeyn, Cynthia A.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3987868/
https://ncbi.nlm.nih.gov/pubmed/20494390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2010.04.010
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