Construction of a Chimeric Secretory IgA and Its Neutralization Activity against Avian Influenza Virus H5N1

Secretory immunoglobulin A (SIgA) acts as the first line of defense against respiratory pathogens. In this assay, the variable regions of heavy chain (VH) and Light chain (VL) genes from a mouse monoclonal antibody against H5N1 were cloned and fused with human IgA constant regions. The full-length c...

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Bibliographic Details
Main Authors: Li, Cun, An, Xiaoping, Butt, Azeem Mehmood, Zhang, Baozhong, Zhang, Zhiyi, Wang, Xiaona, Huang, Yong, Zhang, Wenhui, Zhang, Bo, Mi, Zhiqiang, Tong, Yigang
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2014
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3987799/
https://ncbi.nlm.nih.gov/pubmed/24741594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/394127
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