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The Contribution of Ciliary Neurotrophic Factor Receptors to Adult Motor Neuron Survival In Vivo Is Specific to Insult Type and Distinct From That for Embryonic Motor Neurons

Exogenous ciliary neurotrophic factor (CNTF) promotes motor neuron (MN) survival following trauma and in genetic models of MN disease. Unconditional disruption of the mouse CNTF receptor α (CNTFRα) gene leads to MN loss, demonstrating a developmental role for endogenous CNTF receptor signaling. Thes...

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Autori principali: Lee, Nancy, Rydyznski, Carolyn E., Spearry, Rachel P., Robitz, Rachel, MacLennan, A. John
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986355/
https://ncbi.nlm.nih.gov/pubmed/23695797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cne.23341
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