The Contribution of Ciliary Neurotrophic Factor Receptors to Adult Motor Neuron Survival In Vivo Is Specific to Insult Type and Distinct From That for Embryonic Motor Neurons

Exogenous ciliary neurotrophic factor (CNTF) promotes motor neuron (MN) survival following trauma and in genetic models of MN disease. Unconditional disruption of the mouse CNTF receptor α (CNTFRα) gene leads to MN loss, demonstrating a developmental role for endogenous CNTF receptor signaling. Thes...

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Hlavní autoři: Lee, Nancy, Rydyznski, Carolyn E., Spearry, Rachel P., Robitz, Rachel, MacLennan, A. John
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986355/
https://ncbi.nlm.nih.gov/pubmed/23695797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cne.23341
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