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Intermolecular β-Strand Networks Avoid Hub Residues and Favor Low Interconnectedness: A Potential Protection Mechanism against Chain Dissociation upon Mutation

Altogether few protein oligomers undergo a conformational transition to a state that impairs their function and leads to diseases. But when it happens, the consequences are not harmless and the so-called conformational diseases pose serious public health problems. Notorious examples are the Alzheime...

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Detalhes bibliográficos
Main Authors: Feverati, Giovanni, Achoch, Mounia, Vuillon, Laurent, Lesieur, Claire
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986249/
https://ncbi.nlm.nih.gov/pubmed/24733378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094745
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