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Analysis of the Robustness of Network-Based Disease-Gene Prioritization Methods Reveals Redundancy in the Human Interactome and Functional Diversity of Disease-Genes
Complex biological systems usually pose a trade-off between robustness and fragility where a small number of perturbations can substantially disrupt the system. Although biological systems are robust against changes in many external and internal conditions, even a single mutation can perturb the sys...
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| Formato: | Artigo |
| Idioma: | Inglês |
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Public Library of Science
2014
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3986215/ https://ncbi.nlm.nih.gov/pubmed/24733074 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094686 |
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