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Direct evidence for activity-dependent glucose phosphorylation in neurons with implications for the astrocyte-to-neuron lactate shuttle

Previous (13)C magnetic resonance spectroscopy experiments have shown that over a wide range of neuronal activity, approximately one molecule of glucose is oxidized for every molecule of glutamate released by neurons and recycled through astrocytic glutamine. The measured kinetics were shown to agre...

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Detalhes bibliográficos
Main Authors: Patel, Anant B., Lai, James C. K., Chowdhury, Golam M. I., Hyder, Fahmeed, Rothman, Douglas L., Shulman, Robert G., Behar, Kevin L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986127/
https://ncbi.nlm.nih.gov/pubmed/24706914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1403576111
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