Evidence for the role of connexin 43-mediated intercellular communication in the process of intracortical bone resorption via osteocytic osteolysis

BACKGROUND: Connexin 43 (Cx43) is the predominant gap junction protein in bone. Mice with a bone-specific deletion of Cx43 (cKO) have an osteopenic cortical phenotype. In a recent study, we demonstrated that cKO mice are resistant to bone loss induced by hindlimb suspension (HLS), an animal model of...

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Autores principales: Lloyd, Shane A, Loiselle, Alayna E, Zhang, Yue, Donahue, Henry J
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3984635/
https://ncbi.nlm.nih.gov/pubmed/24716486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2474-15-122
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