HER2/HER3 heterodimers and p21 expression are capable of predicting adjuvant trastuzumab response in HER2+ breast cancer

Human epidermal growth factor receptor 2 (HER2) plays an important role in breast cancer progression and provides predictive information for response to targeted therapy including trastuzumab although this is limited. Downstream pathways, such as PI3K/Akt, are associated with HER2/HER3 heterodimeriz...

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Hlavní autoři: Green, Andrew R., Barros, Fabrício F. T., Abdel-Fatah, Tarek M. A., Moseley, Paul, Nolan, Christopher C., Durham, Alice C., Rakha, Emad A., Chan, Stephen, Ellis, Ian O.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer US 2014
Témata:
Preclinical Study
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3984415/
https://ncbi.nlm.nih.gov/pubmed/24706169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-014-2925-7
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