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A Two-Dimensional Pooling Strategy for Rare Variant Detection on Next-Generation Sequencing Platforms
We describe a method for pooling and sequencing DNA from a large number of individual samples while preserving information regarding sample identity. DNA from 576 individuals was arranged into four 12 row by 12 column matrices and then pooled by row and by column resulting in 96 total pools with 12...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Public Library of Science
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3984111/ https://ncbi.nlm.nih.gov/pubmed/24728235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0093455 |
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