Male-specific lethal 2, a dosage compensation gene of Drosophila, undergoes sex-specific regulation and encodes a protein with a RING finger and a metallothionein-like cysteine cluster.

In Drosophila the equalization of X-linked gene products between males and females, i.e. dosage compensation, is the result of a 2-fold hypertranscription of most of these genes in males. At least four regulatory genes are required for this process. Three of these genes, maleless (mle), male-specifi...

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Bibliographic Details
Main Authors: Zhou, S, Yang, Y, Scott, M J, Pannuti, A, Fehr, K C, Eisen, A, Koonin, E V, Fouts, D L, Wrightsman, R, Manning, J E
Format: Artigo
Language:Inglês
Published: 1995
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC398407/
https://ncbi.nlm.nih.gov/pubmed/7796814
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