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A novel rapamycin-polymer conjugate based on a new poly(ethylene glycol) multiblock copolymer
PURPOSE: Rapamycin has demonstrated potent anti-tumor activity in preclinical and clinical studies. However, the clinical development of its formulations was hampered due to its poor solubility and undesirable distribution in vivo. Chemical modification of rapamycin presents an opportunity for overc...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3984053/ https://ncbi.nlm.nih.gov/pubmed/24072263 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-013-1192-3 |
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