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A signal peptide missense mutation associated with nicotine dependence alters α2*-nicotinic acetylcholine receptor function
A cytosine to thymidine (C→T) missense mutation in the signal peptide (SP) sequence (rs2472553) of the nicotinic acetylcholine receptor (nAChR) α2 subunit produces a threonine-to-isoleucine substitution (T22I) often associated with nicotine dependence (ND). We assessed effects on function of α2*-nAC...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3984001/ https://ncbi.nlm.nih.gov/pubmed/24467848 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2014.01.021 |
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