A signal peptide missense mutation associated with nicotine dependence alters α2*-nicotinic acetylcholine receptor function

A cytosine to thymidine (C→T) missense mutation in the signal peptide (SP) sequence (rs2472553) of the nicotinic acetylcholine receptor (nAChR) α2 subunit produces a threonine-to-isoleucine substitution (T22I) often associated with nicotine dependence (ND). We assessed effects on function of α2*-nAC...

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Bibliographic Details
Main Authors: Dash, Bhagirathi, Lukas, Ronald J., Li, Ming D.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3984001/
https://ncbi.nlm.nih.gov/pubmed/24467848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2014.01.021
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