Attenuated Bordetella pertussis Vaccine Protects against Respiratory Syncytial Virus Disease via an IL-17–Dependent Mechanism

Rationale: We attenuated virulent Bordetella pertussis by genetically eliminating or detoxifying three major toxins. This strain, named BPZE1, is being developed as a possible live nasal vaccine for the prevention of whooping cough. It is immunogenic and safe when given intranasally in adult volunte...

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Autores principales: Schnoeller, Corinna, Roux, Xavier, Sawant, Devika, Raze, Dominique, Olszewska, Wieslawa, Locht, Camille, Openshaw, Peter J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Thoracic Society 2014
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983892/
https://ncbi.nlm.nih.gov/pubmed/24261996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201307-1227OC
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