Phase Ib of Sorafenib in Combination With Everolimus in Patients With Advanced Solid Tumors, Selected on the Basis of Molecular Targets

BACKGROUND. Molecular alterations of the PI3K and Ras pathways often occur in human cancer. In this trial, the pharmacokinetics, toxicity, and activity of two drugs inhibiting these pathways—everolimus and sorafenib—were investigated. METHODS. Thirteen patients with progressing solid tumors were tre...

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Detalhes bibliográficos
Main Authors: Toffalorio, Francesca, Spitaleri, Gianluca, Catania, Chiara, Dal Zotto, Laura, Noberasco, Cristina, Delmonte, Angelo, Santarpia, Mariacarmela, Vecchio, Fabio, Brunelli, Veronica, Rampinelli, Cristiano, Barberis, Massimo, Fumagalli, Caterina, Zucchetti, Massimo, Zangarini, Monique, Diena, Tullia, Danesi, Romano, de Braud, Filippo, De Pas, Tommaso
Formato: Artigo
Idioma:Inglês
Publicado em: AlphaMed Press 2014
Assuntos:
Clinical Trial Results
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983818/
https://ncbi.nlm.nih.gov/pubmed/24674875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2013-0335
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